LAS VEGAS -- Webb Simpson got the fast start he has looking for -- in the final round at TPC Summerlin and in the PGA Tours new wraparound season. Simpson birdied two of the first three holes Sunday, pulling away for a six-stroke win in the second event of the season. "One over through three yesterday and 2 under today felt like a huge difference," Simpson said. "And it was because it really let me slow down and pace myself, and you know, try to let the guys come after me." Winning for the first time since the 2012 U.S. Open, Simpson closed with a 5-under 66 in the Shriners Hospitals for Children Open. He finished at 24-under 260 after opening with rounds of 64, 63 and 67 to take a four-stroke lead into the final round. "As we were going kind of middle of the round, pins were tough, greens were drying out and I knew it would take a really special round for somebody to shoot 7, 8 under," Simpson said. "So, I felt like I was in control, and I asked my caddie, once I hit it on the green on 17 where we stood. And I was just thankful that I was able to kind of manage my golf ball the last couple rounds." Simpson earned $1.08 million for his fourth PGA Tour title. In addition to the U.S. Open last year at The Olympic Club, he won the Wyndham Championship and Deutsche Bank Championship in 2011. Ryo Ishikawa and Jason Bohn tied for second. Ishikawa, the Japanese player who had to play the Web.com Tour Finals to regain his PGA Tour card, shot a 65. "I wish I could made a couple putts, like three putts," Ishikawa said. "I missed a lot of putts this week, like 10 feet, 15 feet, 20 feet. I missed a lot. But still, Im pretty happy with that result." Bohn had a 66. Charley Hoffman was fourth at 17 under after a 64. "When you get that far up the leaderboard every putt you make is worth big dollars and big FedEx Cup points," Hoffman said. "So, to get the year started off on the right foot, you always want to make those putts." Chesson Hadley, second entering the final round, had a 70 to drop into a tie for fifth at 16 under with Luke Guthrie, Troy Matteson and Charles Howell III. "I was certainly nervous out there today, but I was able just to kind of hang in there," Hadley said. Guthrie and Matteson shot 64, and Howell had a 65. Matteson had seven straight birdies -- on Nos. 9-15 -- to fall one short of the tournament record set by Jerry Kelly in 2003. "It was a really good ball-striking round," Matteson said. "As a matter of fact, when I got to 16, I thought I was going to get that eighth one and I ended up hitting the pin and almost going into the lake, so I would have had a tap-in there. But you know what, all in all its a great end to my week. I didnt quite figure it out in the middle (of the tournament), but I certainly put it together today." 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He allowed just three singles, struck out a season-high 10 and retired 12 of his last 13 batters. Lonnie Chisenhall hit a two-run single in the first off John Lackey (6-4) as the Indians won their fourth straight. Xander Bogaerts hit a two-run homer in the Boston eighth off Bryan Shaw to make it 3-2. Indians left-hander Marc Rzepczynski retired David Ortiz for the final out in the eighth, and Cody Allen worked the ninth for his fourth save. Red Sox shortstop Stephen Drew went 0 for 2 with a walk in his season debut. He re-signed with Boston as a free agent last month. Boston outfielder Grady Sizemore was hitless in four at-bats -- he popped up for the final out -- in his return to Cleveland. Sizemore was a three-time All-Star in nearly eight seasons for the Indians. Cleveland improved to an AL-best 19-11 at home. Masterson was two different pitchers against the Red Sox. His wildness had him flirting with danger in the first and third innings, but he managed to pitch around trouble both times. Masterson needed 61 pitches to get the first nine outs, but he struck out the side in the fourth on just nine pitches. Masterson retired eight in a row before Ortiz singled through Clevelands shift in the sixth. Masterson induced A.J. Pierzynski to hit an inning-ending double play for the second time. Its been that kind of season for Masterson, who has struggled with his control and has not pittched like the All-Star ace the Indians are counting on.dddddddddddd Unable to do anything against Masterson, the Red Sox finally got on the board in the eighth when Brock Holt singled with one out and Bogaerts followed with his fourth homer, a shot into the seats in right-centre. Chisenhalls two-out single gave the Indians an early lead. He has eight RBIs during Clevelands winning streak. With runners at second and third, Chisenhall took Lackeys pitch the opposite way, dropping his single just inside the left-field line. The Indians went up 3-0 in the third when Michael Bourn led off with his fifth triple and scored on Asdrubal Cabreras single. Masterson managed to work in and out of a mess he created for himself in the first. The right-hander gave up a single and two walks before striking out Jonny Gomes, who took exception with plate umpire Phil Cuzzis called third strike on a low fastball. In the third, Masterson gave up a one-out single to Dustin Pedroia and walked Ortiz on four pitches before he got Pierzynski to hit into a double play. NOTES: Indians C Carlos Santana, on the seven-day concussion list, took groundballs as he continues working toward a return to the lineup. Manager Terry Francona said Santana, who has been in a hitting slump all season, could be cleared and back on Friday, when the Indians open a series in Texas. ... Red Sox RHP Clay Buchholz (sprained left knee) is with the team and threw a bullpen session. He will throw another Wednesday before a simulated game on Saturday. ... With Bostons roster loaded with left-handed hitters, the Indians recalled reliever Nick Hagadone from Columbus. Cleveland entered the series with three lefties: Hagadone, Rzepczynski and Josh Outman. ' ' '